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Wissenschaftlicher Hintergrund

NSM Wirkprinzipien

Small Electric fields are predominant directional cues that guide and stimulate the migration of inflammatory cells, fibroblasts and epithelial cells in wound healing.

 

„Naturally occurring, wound-induced electrical signals regulate multiple behaviours of cells and tissues. Harnessing these electrical signals may lead to a paradigm shift in the treatment of ligaments, tendons, muscles and nerves. To my knowledge the NSM therapy is the first to translate this into clinical reality.”

Prof. Colin McCaig, University of Aberdeen 2016

Am Ende ist alles Physik``
Prof. Dr. med. Albrecht Molsberger

Gründer und Erfinder der NSM Therapie

Migration of wound cells

Organs are enclosed by epithelial layers

 

The left video shows the collective migration of fibroblasts in a wound, the direction again depending on the polarity of the field (upper quadrants).

 

Cells lose orientation when specific genes are knocked out or when the intercellular medium is changed in such a way, that electrical cues cannot be transponded.

 

NSM mimics this very fundamental electrophysiological mechanism to accelerate and improve tissue regeneration.

 

Right Video: Fibroblast movement

The right video clip shows one single fibroblast, changing its direction of migration according to the polarity of  the electric field.

 

Wounds in epithelial layers generate small direct currents and small electric fields, being predominant electrical cues for the cellular repair mechanisms of a damaged tissue.

Electrosensitive cells such as fibroblasts and MSCs react to these electric cues and start migration towards the center of the damaged tissue.

Sources:

Zhao M, Song B, Pu J, et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature, 2006;442(7101):457-460.

McCaig CD, Song B, Rajnicek AM. Electrical dimensions in cell science. J Cell Sci, 2009;122(23):4267-4276.

Forschungsprojekte und Kooperationen

Die NSM Therapie zeigt in verschiedenen Indikationsgebieten zum Teil erstaunliche Ergebnisse.``
Dr. med. Gabriele Böwing

Mitgründerin, klinische Forschung

Scientific Projects in Planning

Basic Science

 

Collaborative work on with Colin D McCaig, Jin Pu, Lin Cao. Institute of Medical Sciences, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK

 

  1. Determining the  injury determined electric field (iEF) in animal models with damage in muscles and tendons.
  2. Preparing mesenchymal stem cells (MSCs) from different tissues, including muscle, synovium, periosteum, adipose and bone marrow.
  3. Determining the electrotaxis of different MSCs at different EF strengths to learn whether electrotaxis of MSCs is EF strength dependent.

 

Clinical Studies

 

Headache

  1. NSM in the Treatment of Chronic and Episodic Cluster Headache.  Assessing the mean number of CH attacks per week .Multicenter,single-arm, proof-of-concept trials
  2. NSM in the Treatment of Chronic Cluster Headache – Assessing the mean number of CH attacks per week   Multicentre, Two-Arms, Randomised, Controlled Clinical Trial

Collaborators:  Prof. Hans-Christoph Diener, PD Dr. med. Dagny Holly Universität Essen; PD Dr. med. Charly Gaul, Kopfschmerzklinik Königstein; PD Dr. Med Heike Israel, Charité Berlin,  Prof. Andreas Straube, Klinikum der Universität München. Statistics: Clinical Trial Support, Dr. Med. A. Drabik, Muenster, Germany

 

Sports Medicine

  1. NSM in the Treatment of Achilles tendinits   Assessing Symptom Severity with the VISA Score:
    A Multicentre, Two-Arms, Randomised, Controlled Clinical Trial
  2. NSM in the Treatment of Patellar tendinits   Assessing Symptom Severity with the VISA Score:
    A Multicentre, Two-Arms, Randomised, Controlled Clinical Trial

 

Collaborators: Prof. Peter Angele, Dr. Heinz-Jürgen Eichhorn, Straubing, Univ. Regensburg; Dr. Peter Schäferhoff, Dr. Hauke Dewitz, Dr. Paul Klein, Mediaparkklinik Köln; Dr. Andreas Graeb, München; Prof. Stengel, Unfallkrankenhaus Berlin, Lutz Neumann, Sportorthopädie Bremerhaven. Statistics: Clinical Trial Support, Dr. Med. A. Drabik, Muenster, Germany

2015 / 2016 – NSM Therapy for chronic Achilles Tendinitis And Patellar Tendinitis – Prospective Case Series Study

Achilles Study:

25 patients with chronic Achilles tendinitis received 1-6 (mean 4) NSM treatments within 3 weeks (compassionate use). All .25 patients provided data directly after treatment, 22 patients provided data for follow up at 12 and 52 weeks.

 

 

Patelllar Study:

25 patients with chronic Patellar tendinitis received 1-6 (mean 4) NSM treatments within 3 weeks (compassionate use). All .25 patients provided data directly after treatment, 23 patients provided data for follow up at 12 and 52 weeks.

The following graphs refer to the main outcome of the  Achilles Study. The Patellar Study shows similar results.11 PBS: 0=no pain at all, 10= unbearable pain; Visa Score: 0= complete loss of function, 10=complete and normal function

 

Full biometrical SAS report by Clinical Trial Support, Dr. Med. A. Drabik, Muenster, Germany,( provided on request).

NSM Therapy for Chronic Cluster Headache (CCH)

Sub-study on case series of Chronic Cluster Headache – Monocentric Prospective Observational Study

 

Data refer to 20 (PPP = 18) patients with Chronic Cluster Headache, who received 3 NSM treatments within a treatment phase of 28 days. The evaluation of efficacy is focussed on the within-patient pre-post-comparison of baseline values with follow-up‑values of week 2, 4, 6, 8, 12, 24. Main Efficacy variables from patients’ diaries are: Number of CH-attacks per day and 50%-reduction of number of CH-attacks per day; other efficacy variables refer to the intake of concomitant pain medication / treatment.

 

Full biometrical SAS report by C. Glasmacher, Munich Germany (provided on request).

Wissenschaftlicher Beirat

schumann

Prof. Dr. Wolfgang Schuhmann

 

Ruhr-University Bochum, Center for Analytical Chemistry and Electrochemistry

 

Collaboration: Investigation on specific electrochemical cell reactions in the skin and underlying tissue, development of specific NSM probes.

maixner

Prof. Dr. William Maixner

 

Duke University, School of Medicine, Department of Anesthesiology,
Head of Translational Pain Medicine

 

Collaboration: NSM treatment in pain condition, research support in pain

mccaig

Prof. Dr. Colin McCaig

 

Aberdeen: The Institute of Medical Sciences, Regis Professor of Physiology

 

Collaboration: joint clinical / basic science project on electrical induced enhanced tendon and ligament repair. The effect of electrical fields through selectively inducing directed migration of MSCs.

Naturally occurring, wound-induced electrical signals regulate multiple behaviours of cells and tissues. Harnessing these electrical signals may lead to a paradigm shift in the treatment of ligaments, tendons, muscles and nerves. To my knowledge the NSM therapy is the first to translate this into clinical reality.”
Prof. Colin McCaig, University of Aberdeen 2016

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